Risks of serious side-effects. Older antipsychotics (known as "typical" antipsychotics) have been around since the mid-1950s. These varying effects explain the potential differences in adverse effect profiles, listed in TABLE 2. Typical antipsychotics are not particularly selective and also block dopamine receptors in the mesocortical pathway, tuberoinfundibular pathway, and the nigrostriatal pathway. Typical antipsychotics (also known as major tranquilizers, or first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia).Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions. MAOI side effects MAOIs tend to have multiple side effects, many of them serious and harmful. Serious Abilify side effects include tardive dyskinesia and neuroleptic malignant syndrome. However, evidence suggests that atypical antipsychotics are not as unencumbered by side effects as once believed. There is a significant risk of the serious condition tardive dyskinesia developing as a side-effect of typical antipsychotics. In fact, they are more likely to cause type 2 diabetes and weight gain. Common Abilify (aripiprazole) side effects include nausea, vomiting, headache, insomnia and weight gain. Blocking D 2 receptors in these other pathways is thought to produce some unwanted side effects that the typical antipsychotics can produce (see above). The risk of developing tardive dyskinesia after chronic typical antipsychotic usage varies on several factors, such as age and gender. MAOIs also have the potential for dangerous interactions with foods and over-the … Newer antipsychotics (known as "atypical" antipsychotics) were developed in the 1990s. Abilify withdrawal … Stopping Abilify may cause withdrawal.
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