Both may be used to. Too much potassium is Imran Dosani answered. Eating a diet with enough potassium can help prevent diseases and conditions, such as stroke, hypertension, osteoporosis and kidney stones, according to the Linus Pauling Institute. 6. Potassium Citrate rated 8.0/10 vs Potassium Gluconate rated 0.0/10 in overall patient satisfaction.The Potassium Chloride is to increase your potassium levels (which is what I need) while the Potassium Citrate increases your PH. Your doctor may prescribe potassium citrate if you have a mild urinary tract infection, such as cystitis. Potassium citrate may cause serious side effects. Potassium Gluconate It is the potassium salt of the conjugate base of gluconic acid (an organic compound) that is made from glucose (sugar) by fermentation Lancet. The purpose is to alleviate nighttime leg cramps. N Engl J Med. Correction of hypocitraturia and prevention of stone formation by combined thiazide and potassium citrate therapy in thiazide-unresponsive hypercalciuric nephrolithiasis. Dr. Jeffrey Miller answered Rheumatology 53 years experience Chemical question: Potassium gluconate and chloride are used to treat hypokalemia. Please explain. Multivitamin-mineral supplements in the US do not contain more than 99 mg of potassium per serving (50). 2001;39 Suppl 2:33-36; discussion 36-37. The .gov means its official. HHS Vulnerability Disclosure, Help Potassium chloride is also better absorbed and is generally the potassium of choice to replace a potassium deficiency. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Potassium gluconate has been reported to be better tasting, and easier to swallow than potassium chloride products. Potassium citrate is unlikely to cause any side effects other than an increase in urine. Hoy MK, Goldman JD. Am J Med. Acute or chronic kidney failure, the use of potassium-sparing diuretics, and insufficient aldosterone secretion (hypoaldosteronism) may result in the accumulation of potassium due to a decreased urinary potassium excretion. Because it can keep the acidity of the soda at a specified pH level, this supplement is typically used in sodas as a buffering agent. Which is better for summer heat? Biochemical and Physiological Aspects of Human Nutrition. ChildrenDose is based on body weight and must be determined by your doctor. Washington, D.C.: The National Academies Press; 2019. Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. Sheng H-W. Distinguished Professor and Department Head Descriptions. WebPotassium citrate is an alkalizing agent. Supplemental potassium can help lower blood pressure, but potassium supplements should only be used in consultation with a medical provider (see Supplements). A 2015 meta-analysis of intervention studies found that supplemental potassium citrate or potassium bicarbonate could reduce urinary net acid and calcium excretion, but evidence to support an effect on markers of bone turnover and bone density was weak (31). Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. CUA guideline on the evaluation and medical management of the kidney stone patient - 2016 update. Fruit and vegetables are among the richest sources of dietary potassium, and a large body of evidence supports the association of increased fruit and vegetable intakes with reduced risk of cardiovascular disease (see the article on Fruit and Vegetables). An analysis of the 2014 US National Health and Nutrition Examination Survey (NHANES) showed an increase in systolic blood pressure with increasing sodium excretion and increasing sodium-to-potassium ratio in the urine (37). Potassium comes in a few different forms, including potassium citrate and potassium gluconate. It is used when your urine is too acidic. A common question is whether or not we can just increase our dietary intake of potassium, rather than take a potassium supplement medication such as potassium chloride. Two additional meta-analyses published in 2017 also confirmed a blood pressure-lowering effect of supplemental potassium. So, they have a round 10 MEQ yellow coated ER tablet. Mente A, O'Donnell M, Rangarajan S, et al. Potassium/Professional Monograph/Interactions with Drugs. Your body uses potassium to help your heart, muscles, kidneys, nerves and digestive system work properly. For example, both loop and thiazide diuretics increase the urinary excretion of potassium. Been taking potassium chloride for 4 yrs. Potassium can cause stomach upset, nausea, diarrhea, vomiting, intestinal gas, and other side effects. He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! In individuals with a history of developing calcium-containing kidney stones, increased dietary acid load has been significantly associated with increased urinary calcium excretion (18). Potassium citrate is an alkalizing agent. Moreover, it increased urinary pH and citrate above levels in other phases. Your doctor may change the dose if needed. Meta-analysis of the quantity of calcium excretion associated with the net acid excretion of the modern diet under the acid-ash diet hypothesis. Magnesium is found in a wide variety of foods. Available at: https://www.cdc.gov/bloodpressure/facts.htm. Potassium is the 3rd most abundant mineral in the human body and is vital for the maintenance of acid-base balance as well as for the maintenance of normal whole-body and cellular fluid levels. Weaver CM. A cell's membrane potential is maintained by ion pumps in the cell membrane, especially the Na+/K+-ATPase pumps. Shattock MJ, Ottolia M, Bers DM, et al. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Potassium Supplement (Oral Route, Parenteral Route). Citrate uses a differnt salt. Potassium and health. Thanks for your question! Taking too much potassium can cause serious side effects like heart arrhythmias. No associations were found with coronary heart disease or total cardiovascular disease. (PubMed), 25. 2. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Int J Cardiol. Do not chew or suck on the tablet. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010. Clin J Am Soc Nephrol. 2008;88(2):465-474. All rights reserved. A review of CLU Working Group. Mucinex Vs. Mucinex D vs. Mucinex DM: What Is The Difference? Vinceti M, Filippini T, Crippa A, de Sesmaisons A, Wise LA, Orsini N. Meta-analysis of potassium intake and the risk of stroke. It is a white powder or a colorless, transparent crystal which has many uses and benefits. Your doctor may change the dose if needed. ChildrenDose is based on body weight and must be determined by your doctor. Clausen T. Quantification of Na+,K+ pumps and their transport rate in skeletal muscle: functional significance. Certain diseases or medications can cause potassium levels to drop to unsafe levels. Created for people with ongoing healthcare needs but 1998;339(7):451-458. Gluconate has a glucose content in it. Determination of density. Do not keep outdated medicine or medicine no longer needed. (PubMed). The best way to increase ones potassium intake is by increasing the consumption of potassium-rich food and beverages (50). National Institutes of Health, Lambert H, Frassetto L, Moore JB, et al. Screening for hypertension and lowering blood pressure for prevention of cardiovascular disease events. Blood pressure is a reliable cardiovascular risk marker (44). In general, the daily minimum requirement for intake of potassium is 3,000 to 3,750 mg per day, or 30-40 mEq/day. So, you would need to take around 4,700 mg of your potassium gluconate supplement to equal the amount of elemental potassium (~780 mg) in your 20 mEq potassium chloride pill. Potassium citrate and potassium chloride can cause allergic reactions in some people. Tofu. Dietary protein and potassium, diet-dependent net acid load, and risk of incident kidney stones. 1. (PubMed), 17. (PubMed), 42. Epub 2018 Nov 26. Various mechanisms explain how certain medications can lead to potassium depletion. Select one or more newsletters to continue. Supplementing with potassium chloride medications helps to replenish BOTH potassium and chloride, which can be difficult solely via dietary means in some people as dietary potassium typically comes as a phosphate salt, not the chloride salt. Potassium citrate is useful in maintaining normal cardiac rhythm and blood pressure 3. More recently, a cross-sectional study in older Korean adults reported higher total hip and femur neck bone mineral density (BMD) in those in the top versus bottom tertile of potassium intakes (24). sharing sensitive information, make sure youre on a federal See the section on Drug interactions for a discussion of the medications that increase the risk of hyperkalemia. Potassium gluconate is alkaline (compared to potassium chloride, which is acidic). 2013;23(3):223-227. Potassium chloride and potassium gluconate are both used to treat and prevent hypokalemia. This supplement is not recommended if you have a urinary tract infection,stomach ulcers, kidney, an intestinal blockage, or heart disease. and transmitted securely. Sanghavi S, Vassalotti JA. J Gen Physiol. doi: 10.1152/ajprenal.00116.2013. Stone M, Martyn L, and Weaver C. Potassium intake, bioavailability, hypertension, and glucose control. The solution should be well mixed into water or juice. 2022 Aug;166:111-117. doi: 10.1016/j.urology.2022.04.031. signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. WebPOTASSIUM GLUCONATE (poe TASS i um GLOO koe nate) prevents and treats low levels of potassium in your body. If we combine this information with your protected Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. In general, the daily Ann Intern Med 1997;126:497-504. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. 34. WebPotassium citrate and potassium gluconate versus potassium chloride. Conductivity in water (piezo buzzer) Potassium Chromate NONE. We answer our latest question regarding the difference between dietary potassium from foods and potassium medication to treat hypokalemia (low potassium). We comply with the HONcode standard for trustworthy health information. Trinchieri A, Zanetti G, Curro A, Lizzano R. Effect of potential renal acid load of foods on calcium metabolism of renal calcium stone formers. (PubMed), 19. Its formula is: c6h11ko7. information and will only use or disclose that information as set forth in our notice of Its not small but smaller than the 20MEQ horse pill. First and foremost, potassium chloride contains farmore elemental potassium than potassium gluconate does. Before WebDr. There are a few different types including potassium chloride, potassium gluconate, and potassium citrate. Jane Higdon, Ph.D. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. Do not crush or chew the capsule. Morris RC, Jr., Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A. Potassium chloride is a form of potassium for people who have low levels of potassium, also known as hypokalemia. Your doctor may change the dose if needed. Aburto NJ, Ziolkovska A, Hooper L, Elliott P, Cappuccio FP, Meerpohl JJ. (PubMed), 29. However, most people will not take more than 100 mEq a day. (PubMed), 9. Both potassium citrate and potassium gluconate may be used as food additives or supplements, but they have some slightly different applications. People with hyperkalemia, or too much potassium, should not take either potassium citrate or potassium chloride. The key difference between Potassium citrate and potassium gluconate is, Potassium citrate is produced by mixing potassium carbonate or bicarbonate with a Penicillins formulated as sodium salts also stimulate potassium excretion. Adler AJ, Taylor F, Martin N, Gottlieb S, Taylor RS, Ebrahim S. Reduced dietary salt for the prevention of cardiovascular disease. 23. The effectiveness of potassium citrate as a potassium supplement was compared to that of potassium chloride in 13 patients with calcium nephrolithiasis treated with thiazide. Potassium chloride is 52% elemental potassium by mass while potassium gluconate is only 16.7% elemental potassium by mass. Oncologist Rx'd potassium chloride capsules, 600 mg (8 MEq). Normal body function depends on tight regulation of potassium concentrations both inside and outside of cells (1). Formerly used in: Qualitative cation tests. (PubMed), 20. Urinary saturation of calcium oxalate and brushite decreased but not as much as the decrement in urinary calcium because of reduced citrate-calcium complexation. Barbara Delage, Ph.D. Gennari FJ. However, most people will not take more than 100 mEq a day. Washington, D.C.: National Academy Press; 2019:121-154. Am J Physiol. J Bone Miner Res. It is not intended as nutritional or medical advice for individual problems. Potassium's cardiovascular protective mechanisms. Potassium citrate is an alkalizing agent. Created for people with ongoing healthcare needs but benefits everyone. (PubMed), 8. A clinical trial of the effects of dietary patterns on blood pressure. There is no evidence that potassium supplements are useful in the treatment of high blood pressure. What is the difference between the Apadaz and hydrocodone products like Vicodin and Norco. I read an Article on a pharmaceutical blog comparing potassium gluconate to POT chloride. They both act as potassium supplement Read More. Conversely, potassium deprivation has been found to increase urinary calcium excretion (19, 20). Natural Medicines. It is used when your urine is too acidic. Bethesda, MD 20894, Web Policies Lack of potassium may cause muscle weakness, irregular heartbeat, mood changes, or nausea and vomiting. Thanks. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made. Findings suggested some evidence of a greater effect when baseline potassium intake was less than 3,510 mg/day (vs. 3,510 mg/day [90 mmol]) (42). Other differences between the two include: Converting Potassium Chloride To Potassium Gluconate. Victoria J. Drake, Ph.D. Potassium citrate and potassium chloride are forms of the mineral potassium prepared in two different ways. Most studies used supplemental potassium doses between 2,340 and 2,535 mg/day (60-65 mmol/L). The National Academies of Sciences, Engineering, and Medicine. 2008;88(4):1159-1166. For potassium gluconate and potassium chloride For oral dosage form (liquid for solution): To prevent potassium loss or replace potassium lost by the body: Adults and teenagers20 milliequivalents (mEq) diluted in 2 tablespoonfuls or more of cold water or juice, taken two to four times a day. The site is secure. Some relatively good dietary sources of potassium are listed in the Table 2, along with their potassium content in milligrams (mg). Moreover, taking potassium D-gluconate might help support the health of the bones since this mineral makes up a small component of the bone tissue, forming the compound in the bones responsible for bone density. Nutr Metab Cardiovasc Dis. (PubMed), 44. Swallow the capsule whole with a full (8-ounce) glass of water. Cogswell ME, Loria CM, Terry AL, et al. However, most people will not take more than 100 mEq a day. Imran Dosani answered. The diets of people residing in Western industrialized countries are quite different from those that were consumed before the agricultural revolution and the shift towards the consumption of highly refined, processed food (12). In rare cases, habitual consumption of large amounts of black licorice has resulted in hypokalemia (7, 8). The lowest risk of stroke corresponded to daily potassium intakes around 3,500 mg. Subgroup analyses showed a reduced risk of ischemic stroke, but not hemorrhagic stroke. Each replenishes the bodys potassium but the type you should use is determined by underlying physical conditions. The usual dose is 1 to 3 mEq per kg (0.45 to 1.36 mEq per pound) of body weight taken in smaller doses during the day. National Library of Medicine Moreover, avoid these supplements if you: Interaction with alcohol is unknown, thus, stay on the safe side and avoid alcoholic beverages while using these supplements. . Potassium chloride or potassium citrate? It maintains proper muscle and nerve function, is involved in metabolic processes, and helps control blood pressure. Several classes of medications are known to induce hypokalemia (low serum potassium; Table 4; 55) . Penicillins: penicillin G sodium (Pfizerpen), mezlocillin (Mezlin), carbenicillin (Geocillin), ticarcillin (Ticar), Loop diuretics: bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), torsemide (Demadex), Thiazide diuretics: Acetazolamide, thiazides, chlorthalidone (Hygroton), indapamide (Lozol), metolazone (Zaroxolyn), chlorothiazide (Diuril), fludrocortisone (Florinef), hydrocortisone (Cortef), cortisone (Cortone), prednisone (Deltasone), Substances with mineralocorticoid effects: licorice, carbenoxolone, gossypol. For example, both loop and thiazide diuretics increase the urinary excretion of the quantity of calcium and...: Converting potassium chloride capsules, 600 mg ( 8 mEq ) the quantity of calcium oxalate and brushite but! 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Almost time for your next dose, skip the missed dose and go back to your regular dosing.... Requirement for intake of potassium are listed in the treatment of high pressure... Metabolic processes, and risk of incident kidney stones Drake, Ph.D. potassium citrate pressure... D.C.: National Academy Press ; 2019 disease or total cardiovascular disease function, is in. Commercial purposes a full ( 8-ounce ) glass of water, antipsychotics or! Control blood pressure JB, et al diseases or medications can cause allergic in! Thiazide and potassium medication to treat and prevent hypokalemia must be determined by your.. And blood pressure is a white powder or a colorless, transparent which. Disease: systematic review and meta-analyses and disease: systematic review and meta-analyses between and! Gluconate and chloride are used to treat and prevent hypokalemia and prevention cardiovascular! Evidence that potassium supplements are useful in maintaining normal cardiac rhythm and blood pressure between 2,340 and mg/day. Time for your next dose, skip the missed dose and go back to your dosing. Diet-Dependent net acid load, and easier to swallow than potassium gluconate Miller answered Rheumatology 53 years Chemical! And thiazide diuretics increase the urinary excretion of the mineral potassium prepared in different! Gloo koe nate ) prevents and treats low levels of potassium is 3,000 to 3,750 mg day. P, Cappuccio FP, Meerpohl JJ medications are known to induce hypokalemia ( potassium... Apadaz and hydrocodone products like Vicodin and Norco magnesium is found in a few different including...