The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. READ PAPER. This type of liver cancer tends to develop in people who have: Liver & intrahepatic bile ducts nontumor . Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. Increased risk for bacterial cholangitis and cholangiocarcinoma (Clin Liver Dis 2016;20:67) Up to 70% also have inflammatory bowel disease (particularly ulcerative colitis , although fewer than 10% with ulcerative colitis have primary sclerosing cholangitis) ( Gut Liver 2018;12:17 ) This cytokine is mainly secreted by macrophages. Page views in 2021 to date (this page and chapter topics): 372,701 18 Full PDFs related to this paper. It starts in the tubelike structures called bile duct cells that deliver bile, a substance that helps in digesting food. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. First Aid USMLE STEP 2 CK This gene is a member of the PDGF/VEGF growth factor family. Intrahepatic cholangiocarcinoma is the second most common type of primary liver cancer.
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