All atypical antipsychotics can have similar side effects, but some agents have an advantage over another. Typical antipsychotics (neuroleptics) should always be avoided in the management of patients with LBD, especially DLB, who risk severe worsening of all symptoms, and, as mentioned above, may develop potentially fatal NMS. They should consider the importance of each outcome, the patients' medical problems, and preferences. Alternatively, olanzapine does not cause Torsade de Pointes (more on this here). There are some efficacy differences between antipsychotics, but most of them are gradual rather than discrete. QTc prolongation can occur with quetiapine to a slight extent. Differences in side-effects are more marked. These findings will aid clinicians in balancing risks versus benefits of those drugs available in their countries. Atypical antipsychotics may still occasionally cause extrapyramidal symptoms (but less so than butyrophenones). For example, If weight gain is a concern for you, you might discuss with your doctor which medicines have a low chance of causing this side effect. First-generation antipsychotics (sometimes called typical antipsychotics) are older medications, first starting to be developed in the 1950s. These agents are relatively contraindicated in Parkinson's disease. Typical antipsychotics (also known as major tranquilizers, or first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia).Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.
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