View abstract. [The effect of an extract of Baikal skullcap (Scutelleria baicalensis) on succinic acid oxidation by the brain mitochondria in rats with hypoxia]. View abstract. 1997;57(1):63-67. Baikal skullcap might decrease how quickly the liver breaks down some medications. Papafragkakis C, Ona MA, Reddy M, Anand S. Acute hepatitis after ingestion of a preparation of Chinese skullcap and black catechu for joint pain. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Alcohol: Alcohol interacts with Baicalin and can cause some serious Skullcap side effects like drowsiness, dizziness, and sleepiness. Low blood pressure: Baikal skullcap might lower blood pressure. View abstract. View abstract. Stop using Baikal skullcap at least 2 weeks before a scheduled surgery. A Medicinal Plant Extract of Scutellaria Baicalensis and Acacia Catechu Reduced LPS-Stimulated Gene Expression in Immune Cells: A Comprehensive Genomic Study Using QPCR, ELISA, and Microarray. Adam T, Bursztejn AC, Schmutz JL. Mol Pharmacol 2001;60(3):507-513. This is especially relevant to macrophages and immune cells. View abstract. 1-19-2007;109(2):325-330. Scutellaria baicalensis extract containing baicalin (a flavone, type of flavonoid, is a major bioactive compound) has been used in traditional View abstract. Planta Med 2010;76(7):678-682. Life Sci 10-27-2000;67(23):2889-2896. View abstract. Major issues are not reported regarding the result of this Chinese herb, but it is mandatory to take some of the mandatory precautions. A large long-term population study identifies S. barbata among the single herbs used in TCM that may reduce risk of hepatocellular carcinoma in hepatitis B patients(9). Dong R, Li L, Gao H, et al. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. Pharmacol Biochem Behav 2009;92(4):642-648. Pediatr Dermatol 2006;23:507-10. View abstract. Zhao, Y., Li, H., Gao, Z., Gong, Y., and Xu, H. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. 2020 May;82(5):307-309. Cancer Res 7-15-2003;63(14):4037-4043. Chinese Journal of Gerontology 2010;30(7):926-928. Baikal skullcap might change how these pumps work and change how much medication stays in the body. View abstract. 2007;60(5-6):294-297. It is also used as a diuretic, and should not be confused with Scutellaria baicalensis. J Nat Prod 1997;60(6):598-601. Toxicology 5-2-2009;259(1-2):10-17. Biochem Biophys Res Commun 9-24-2000;276(2):534-538. Ju, W. Z., Liu, F., Wu, T., Xia, X. Y., Tan, H. S., Wang, X., and Xiong, N. N. [Simultaneous determination of baicalin and chlorogenic acid in human plasma by UPLC-MS/MS]. Clin Pharmacol Ther 2007;83:471-6. View abstract. View abstract. There have been reports of fever and lung 1998;61(2):54-56. View abstract. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. Biomed Res Int 2016;2016:5697571. S. barbata also prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress(31)and increasing superoxide dismutase levels(16). (Elite.Ed) 2010;2:1538-1547. View abstract. Side effects are few and may include drowsiness. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1. Chem Pharm Bull (Tokyo) 1992;40(2):531-533. View abstract. Different extracts of this herb have been found to kill cancer cells in the body, but human research is pending in this field. Before taking Baikal skullcap, talk to your healthcare provider if you take any medications that are changed by the liver. View abstract. Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. Baikal skullcap might have an effect like a water pill or "diuretic." 1998;61(2):54-56. Ding, X. F., Gao, H. N., Guo, X. H., Wang, Z. Dosage: 39 g/day/adult. Fu, J., Cao, H., Wang, N., Zheng, X., Lu, Y., Liu, X., Yang, D., Li, B., Zheng, J., and Zhou, H. An anti-sepsis monomer, 2',5,6',7-tetrahydroxyflavanonol (THF), identified from Scutellaria baicalensis Georgi neutralizes lipopolysaccharide in vitro and in vivo. Yang, L., Zheng, X. L., Sun, H., Zhong, Y. J., Wang, Q., He, H. N., Shi, X. W., Zhou, B., Li, J. K., Lin, Y., Zhang, L., and Wang, X. Catalase suppression-mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor-induced NF-kappaB activation and sensitizes apoptosis. Br J Pharmacol 2009;157:1410-18. View abstract. Common substitutions for Baikal skullcap in Chinese medicine include related plants whose scientific names are Scutellaria viscidula, Scutellaria amonea, and Scutellaria ikoninikovii. BMC.Complement Altern Med 2006;6:27. Interactions Do not use Chinese skullcap with alcohol or the following View abstract. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. View abstract. Accessed Sept 30, 2016. View abstract. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. View abstract. 73.^ Hwang YK, Jinhua M, Choi BR, Cui CA, Jeon WK, Kim H, Kim HY, Han SH, Han JS Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments J Ethnopharmacol. Baikal skullcap might cause sleepiness and drowsiness. View abstract. Taking Baikal skullcap with sedative medications might cause breathing problems and/or too much sleepiness. Diabetes medications are also used to lower blood sugar. View abstract. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Whether co-administration of garlic has negative influence on Scutellaria baicalensis Georgi in treating models rats with pelvic inflammation? Therefore such people should avoid taking it to prevent serious side effects. Monitor your blood sugar closely. Sonoda, M., Nishiyama, T., Matsukawa, Y., and Moriyasu, M. Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. Chen C, Mireles RJ, Campbell SD, et al. J Biomed.Sci 2009;16:27. The growing interest in skin lightening has recently renewed attention on the esthetic applications of Chinese herbal medicine. J Ethnopharmacol. Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. Chen, S., Yuan, Y., Luo, Y., Huang, L., Chen, P., and Li, X. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. You, J., Gao, S., Jin, H., Li, W., Zhang, H., and Yu, A. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. The root is used to make medicine. WebBaicalin extracts have strong anti-inflammatory effects. 11-28-2000;160(2):219-228. December 19, 2017. Planta Med 2000;66:70-1. Details. Kimura, Y., Yokoi, K., Matsushita, N., and Okuda, H. Effects of flavonoids isolated from scutellariae radix on the production of tissue-type plasminogen activator and plasminogen activator inhibitor-1 induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells. FDA Alerts Consumers About Potentially Life-Threatening Health Problems Linked to Limbrel. Kong XT, Fang HT, Jiang GQ, et al. Wang R.T, Zhang J.X, and Dong Y.J. Liao JF, Wang HH, Chen MC, et al. Arch Dis Child 1993;68:468-71. Zhang H and Huang J. Some of these medications that are changed by the liver include amitriptyline (Elavil), carisoprodol (Soma), citalopram (Celexa), diazepam (Valium), lansoprazole (Prevacid), omeprazole (Prilosec), phenytoin (Dilantin), warfarin (Coumadin), and many others. View abstract. This will help them manage your care and keep you safe. View abstract. View abstract. Side Effects Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. View abstract. WebScutellaria baicalensis, a medicinal herb belonging to the Lamiaceae family, has been recorded in the Chinese, European, and British Pharmacopoeias. Baikal skullcap might lower blood sugar levels. Anticancer Res 2007;27(1A):117-125. View abstract. View abstract. View abstract. This Chinese herb may slow down blood clotting, increasing the risk of bleeding and bruising in people who already have some bleeding disorders. Blaszczyk T, Krzyzanowska J, Lamer-Zarawska E. Screening for antimycotic properties of 56 traditional Chinese drugs. Levy RM, Saikovsky R, Shmidt E, et al. This could change the effects and side effects of these medications. View abstract. Baikal skullcap might decrease blood sugar. 2020;318(1):E52-E61. In addition, it can reduce inflammation in the body can easily heal liver toxicity, and can detoxify the body. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. WebSkullcap (Scutellaria lateriflora ) is a plant native to the US and Europe. Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patients with lung cancer. Am J Chin Med 2001;29(1):69-81. Arjmandi BH, Ormsbee LT, Elam ML, et al. Polysaccharides in S. barbata demonstrate antioxidant and free radical-scavenging activity(15). Information from this source is evidence-based and objective, and without commercial influence. Apoptotic effects with the alkaloid scutebarbatine A occurs via cytochrome c and caspase-3/9 upregulation, and Bcl-2 downregulation(28). Available at: https://www.cancer.gov/about-cancer/treatment/cam/hp/pc-spes-pdq. Hou, Y. C., Lin, S. P., Tsai, S. Y., Ko, M. H., Chang, Y. C., and Chao, P. D. Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats. Baikal skullcap might change how quickly the liver breaks down these medications. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Ready to start planning your care? View abstract. Taking Baikal skullcap might decrease how well the body gets rid of lithium. A traditional Chinese herbal medicine loaded with potent antioxidant and anti-inflammatoryflavonoids such as baicalin, baicalein, and wogonin. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. Children: Baikal skullcap is POSSIBLY SAFE in children when given intravenously (by IV) by a healthcare provider, short-term. Bochorakova, H., Paulova, H., Slanina, J., Musil, P., and Taborska, E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Krskova, Z., Martin, J., Pec, J., and Dusek, J. There is concern that it might cause extra bleeding during and after surgery. Kimura, Y., Okuda, H., and Ogita, Z. Yim, J. S., Kim, Y. S., Moon, S. K., Cho, K. H., Bae, H. S., Kim, J. J., Park, E. K., and Kim, D. H. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. It is also used for gastrointestinal (GI) infections, as well as liver problems including viral hepatitis and jaundice. [Application of XRF to the analysis of Scutellaria baicalensis with space mutagenesis]. Chen C, Mireles RJ, Campbell SD, et al. View abstract. View abstract. [Study on the inhibitory activity, in vitro, of baicalein and baicalin against skin fungi and bacteria]. J Chem Ecol. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. 5-17-2011;135(2):359-368. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Ciesielska, E., Wolszczak, M., Gulanowski, B., Szulawska, A., Kochman, A., and Metodiewa, D. In vitro antileukemic, antioxidant and prooxidant activities of Antoksyd S (C/E/XXI): a comparison with baicalin and baicalein. View abstract. View abstract. Yeh J.H, Chiu H.F, Wang J.S., and et al. Am J Physiol Endocrinol Metab. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. J Med Chem 10-21-2004;47(22):5555-5566. Liu, J. J., Huang, T. S., Cheng, W. F., and Lu, F. J. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. Yin, F., Liu, J., Ji, X., Wang, Y., Zidichouski, J., and Zhang, J. Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells. View abstract. Hu, J. Consult your Doctor if you are Pregnant and Breastfeeding. It is not an approved drug. View abstract. J Cell Biochem 10-1-2010;111(2):274-283. In theory, Baikal skullcap might lower blood pressure too much in people prone to low blood pressure. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. No matter new buyer or old purchaser, We believe in long expression and trusted relationship for Scutellaria Baicalensis Root, Nootropics Modafinil, Herbal Extract Oil, Maca Extract Liquid, Hawthorn Extract Vs Hawthorn Berry. Lee, Y., Yeo, H., Liu, S. H., Jiang, Z., Savizky, R. M., Austin, D. J., and Cheng, Y. C. Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring. Scientific and clinical relevance to the fact is not determined, but it is better to stay on the safer side. Am J Chin Med 2006;34(2):245-261. View abstract. Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. View abstract. Jiang, R. H., Su, W. C., Liu, H. F., Huang, H. S., and Chao, J. I. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. Sheng, J. P., Chen, H. R., and Shen, L. [Comparative study on selenium and amino acids content in leaves of planted and wild Scutellaria baicalensis]. Planta Med 2002;68(2):128-132. View abstract. Liu, C. Z. and Chen, D. W. [Sanhuang tablets research]. View abstract. View abstract. Planta Med 1998;64:571-2. View abstract. Zhang S, Cheng Z, Huang B, and Li J. Chen, C. S., Chen, N. J., Lin, L. W., Hsieh, C. C., Chen, G. W., and Hsieh, M. T. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. Get medical attention if irritation develops and persists. Scutellaria barbata has been studied for its anticancer properties, but more research is needed. J Cell Biochem 12-15-2010;111(6):1629-1641. Chen, Y., Lu, N., Ling, Y., Gao, Y., Wang, L., Sun, Y., Qi, Q., Feng, F., Liu, W., Liu, W., You, Q., and Guo, Q. Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. View abstract. View abstract. Naunyn-Schmiedeberg Arch Pharmacol 2006;372:432-43. Effects of Mg-ATP on the flavonoid production in the Scutellaria baicalensis Georgii suspension cultures. Lin, A. M., Ping, Y. H., Chang, G. F., Wang, J. Y., Chiu, J. H., Kuo, C. D., and Chi, C. W. Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain. View abstract. In theory, Baikal skullcap might increase the risk of bruising and bleeding in people with bleeding disorders. View abstract. View abstract. However, it is not known if the herb would exert similar effects by itself, and cases of hepatotoxicity with some supplements have been reported(18)(24). Wiad.Lek. Kong XT, Fang HT, Jiang GQ, et al. Planta Med 2006;72(14):1318-1321. ]. Gasiorowski, K., Lamer-Zarawska, E., Leszek, J., Parvathaneni, K., Yendluri, B. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. Baikal skullcap might also lower blood sugar. 2000;23(5):272-274. The pharmacology of Chinese herbs. People with diabetes should not take Chinese skullcap without consulting a doctor as it may lower blood sugar, Kim, E. H., Shim, B., Kang, S., Jeong, G., Lee, J. S., Yu, Y. View abstract. Kumagai, T., Muller, C. I., Desmond, J. C., Imai, Y., Heber, D., and Koeffler, H. P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Mol Pharmacol 2001;60(3):507-513. Due to such properties, it is found that this medicine is prominent in dealing with cancer-producing cells. Scutellaria baicalensisis used in traditional medicine to treat many medical conditions, but studies in humans are limited.S. View abstract. Chemicals in skullcap might cause sleepiness. View abstract. The effect of he jie decoction on the TCRV beta 7 of chronic hepatitis B patients. It can cause drowsiness, fever, lung inflammation, and other information Some cancer cell lines undergo cell death when exposed to extracts of this herb, but some compounds in this herb may actually have opposite effects. Kaplya, O. This might increase the side effects of some medications. But there is not enough information to know if Baikal skullcap is the cause of these side effects. Scutellaria baicalensis | Memorial Sloan Kettering Cancer However, lab tests have shown that it is a herb that can reduce inflammation and have antioxidant properties. Phytother.Res 2003;17(6):640-644. Avoid skin and eye contact and breathing in dust. View abstract. Kowalczyk, E., Krzesinski, P., Kura, M., Niedworok, J., Kowalski, J., and Blaszczyk, J. Baikal skullcap might slow blood clotting. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. You may ask and answer a query. Nishioka T, Kawabata J, Aoyama Y. Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis. There are a number of different names that people use for Baicalin. Acta Pharmacol Sin. View abstract. WebScutellaria baicalensis Root Dry No Data Extract 100 4. Shim K.S, Kim S.N, Kim M.H, and et al. Liu, S., Ma, Z., Cai, H., Li, Q., Rong, W., and Kawano, M. Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells. View abstract. Toxicology 5-2-2009;259(1-2):10-17. View abstract. Cancer Lett. 1987;33(2):80-84. Pneumonitis induced by ou-gon (scullcap). Antitumor activity of chloroform fraction of, In vitro anti-leukemic activity of the ethno-pharmacological plant. Case Reports Heptal 2016;2016:4356749. Lee, S., Kim, D. H., Jung, J. W., Oh, J. H., Park, H. J., Park, C., Huh, Y., Cheong, J. H., Oh, T. H., and Ryu, J. H. Schizandra chinensis and Scutellaria baicalensis counter stress behaviors in mice. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Onco Targets Ther 2016;9:2935-43. By inhibiting tyrosinase, Scutellaria baicalensis root extract may be able to reduce abnormal pigmentation associated with aging and exposure to UV light. Further research is needed to confirm these effects. Zhongguo Zhong.Yao Za Zhi 2001;26(11):768-769. Induction of apoptosis by total flavonoids from. The antiinflammatory and analgesic effects of baicalin in carrageenan-evoked thermal hyperalgesia. Phytother.Res 2009;23(10):1415-1420. It might cause drowsiness. Talk with your healthcare provider before using this product if you are taking lithium. Cao, H., Jiang, Y., Chen, J., Zhang, H., Huang, W., Li, L., and Zhang, W. Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components. But there is not enough information to know if Baikal skullcap is the cause of these side effects. J Agric Food Chem 4-23-2008;56(8):2838-2845. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Have a cup of it daily. In liver tumors, S. barbata flavonoids suppressed angiogenesis via VEGF regulation, MMP2/9 inhibition, and increased TIMP1/2 expression(17)(29). Biomed.Chromatogr. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Zhang, K., Lu, J., Mori, T., Smith-Powell, L., Synold, T. W., Chen, S., and Wen, W. Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Neuroprotective effect of baicalein against MPTP neurotoxicity: Behavioral, biochemical and immunohistochemical profile. In that case, it is either used for hormone synthesis or hormone breakdown, including estrogen and testosterone, which are not advised to combine with the Chinese herb. 2013;140:22-30. In animal models, attenuation of asthma was attributed to reduced airway injury and restored mitochondrial function(19). In vitro and in vivo antitumor activity of scutebarbatine A on human lung carcinoma A549 cell lines. Huang, R. L., Chen, C. C., Huang, H. L., Chang, C. G., Chen, C. F., Chang, C., and Hsieh, M. T. Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Levy RM, Khokhlov A, Kopenkin S, et al. Anticonvulsant effect of wogonin isolated from. Cancer Lett. Integr.Cancer Ther. Yang, X., Huang, S., Chen, J., Song, N., Wang, L., Zhang, Z., Deng, G., Zheng, H., Zhu, X. Q., and Lu, F. Evaluation of the adjuvant properties of Astragalus membranaceus and Scutellaria baicalensis GEORGI in the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. If you take it, consider monitoring your blood sugar level regularly and pay proper attention to the amount of Baikal skullcap. Ann Palliat Med. View abstract. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. 5-17-2011;135(2):359-368. Liu, W., Mu, R., Nie, F. F., Yang, Y., Wang, J., Dai, Q. S., Lu, N., Qi, Q., Rong, J. J., Hu, R., Wang, X. T., You, Q. D., and Guo, Q. L. MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. View abstract. Arch Dis Child 1993;68:468-71. The appropriate dose of Baikal skullcap depends on several factors such as the user's age, health, and several other conditions. Taking Baikal skullcap along with sedative medications might cause too much sleepiness. View abstract. Nat Prod Res 2008;22(16):1410-1412. View abstract. Baicalin is believed to interfere with hormonal reactions and release of histamines and bile in the body; it stimulates gallbladder activity, inhibits inflammation, as well as suppresses the activity of leukaemia-derived T-cells and replication of viruses and bacteria. Planta Med 2011;77(5):455-460. Involvement of p53 in oroxylin A-induced apoptosis in cancer cells. A., and Provalova, N. V. [The modulating effects of preparations of Baikal skullcap (Scutellaria baicalensis) on erythron reactions under conditions of neurotic exposures]. View abstract. 10-18-2009;41(5):578-584. Baikal skullcap (Scutellaria baicalensis) is a plant native to China and Korea. View abstract. View abstract. Li WJ, Bao J, Zheng DC, et al. 4-12-2011;134(3):884-891. 2000;4(3):289-291. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Cancer Chemother.Pharmacol 2011;67(5):1063-1072. 2011;10(2):184-191. Furthermore, this herb has not been treated alone on cancer cells, but it showed results when combined with other herbs and medicines.